RT Journal Article
SR Electronic
T1 Papers of note in <em>Science Translational Medicine</em>
JF Science Signaling
JO Sci. Signal.
FD American Association for the Advancement of Science
SP ec213
OP ec213
DO 10.1126/scisignal.aaj1832
VO 9
IS 445
A1 Ferrarelli, Leslie K.
YR 2016
UL http://stke.sciencemag.org/content/9/445/ec213.abstract
AB CANCERStemming the regrowth of leukemiaInhibition of BCL-2, MCL-1, and BCL-XL eradicates CML stem cells in a mouse model and primary blast crisis samples.B. Z. Carter, P. Y. Mak, H. Mu, H. Zhou, D. H. Mak, W. Schober, J. D. Leverson, B. Zhang, R. Bhatia, X. Huang, J. Cortes, H. Kantarjian, M. Konopleva, M. Andreeff, Combined targeting of BCL-2 and BCR-ABL tyrosine kinase eradicates chronic myeloid leukemia stem cells. Sci. Transl. Med. 8, 355ra117 (2016). [Abstract]LYSOSOMAL STORAGE DISEASESHeat shock protein to the rescueIncreasing HSP70 expression in lysosomes using the small-molecule arimoclomol ameliorates pathology in several animal models of sphingolipidoses.T. Kirkegaard, J. Gray, D. A. Priestman, K.-L. Wallom, J. Atkins, O. D. Olsen, A. Klein, S. Drndarski, N. H. T. Petersen, L. Ingemann, D. A. Smith, L. Morris, C. Bornæs, S. H. Jørgensen, I. Williams, A. Hinsby, C. Arenz, D. Begley, M. Jäättelä, F. M. Platt, Heat shock protein–based therapy as a potential candidate for treating the sphingolipidoses. Sci. Transl. Med. 8, 355ra118 (2016). [Abstract]