PT  - JOURNAL ARTICLE
AU  - Hill, Michael A.
AU  - Braun, Andrew P.
TI  - Oxidant signaling underlies PKGIα modulation of Ca<sup>2+</sup> sparks and BK<sub>Ca</sub> in myogenically active arterioles
AID  - 10.1126/scisignal.aak9385
DP  - 2016 Oct 11
TA  - Science Signaling
PG  - fs15--fs15
VI  - 9
IP  - 449
4099  - http://stke.sciencemag.org/content/9/449/fs15.short
4100  - http://stke.sciencemag.org/content/9/449/fs15.full
SO  - Sci. Signal.2016 Oct 11; 9
AB  - Local blood flow autoregulation in response to intraluminal pressure requires small artery myogenic vasoconstriction, the extent of which is thought to be governed by a feedback process that depends on Ca2+ signaling. In this issue of Science Signaling, Khavandi et al. suggest a role for cyclic guanosine monophosphate (cGMP)–dependent protein kinase G Iα (PKGIα) activated by oxidants in a cGMP-independent manner.