PT - JOURNAL ARTICLE AU - Hill, Michael A. AU - Braun, Andrew P. TI - Oxidant signaling underlies PKGIα modulation of Ca<sup>2+</sup> sparks and BK<sub>Ca</sub> in myogenically active arterioles AID - 10.1126/scisignal.aak9385 DP - 2016 Oct 11 TA - Science Signaling PG - fs15--fs15 VI - 9 IP - 449 4099 - http://stke.sciencemag.org/content/9/449/fs15.short 4100 - http://stke.sciencemag.org/content/9/449/fs15.full SO - Sci. Signal.2016 Oct 11; 9 AB - Local blood flow autoregulation in response to intraluminal pressure requires small artery myogenic vasoconstriction, the extent of which is thought to be governed by a feedback process that depends on Ca2+ signaling. In this issue of Science Signaling, Khavandi et al. suggest a role for cyclic guanosine monophosphate (cGMP)–dependent protein kinase G Iα (PKGIα) activated by oxidants in a cGMP-independent manner.