PT  - JOURNAL ARTICLE
AU  - VanHook, Annalisa M.
TI  - Papers of note in <em>Science </em>
AID  - 10.1126/scisignal.aal2954
DP  - 2016 Nov 01
TA  - Science Signaling
PG  - ec259--ec259
VI  - 9
IP  - 452
4099  - http://stke.sciencemag.org/content/9/452/ec259.short
4100  - http://stke.sciencemag.org/content/9/452/ec259.full
SO  - Sci. Signal.2016 Nov 01; 9
AB  - VASCULAR DISEASEWreaking havoc while (growth-)arrestedSenescent macrophages contribute to early and late stages of atherosclerosis and are potential targets for therapy.B. G. Childs, D. J. Baker, T. Wijshake, C. A. Conover, J. Campisi, J. M. van Deursen, Senescent intimal foam cells are deleterious at all stages of atherosclerosis. Science 354, 472–477 (2016). [Abstract]IMMUNOMETABOLISMMetabolic support for T cell functionsImmunological T cell effector functions are promoted by metabolic activity–modifying levels of histone acetylation.M. Peng, N. Yin, S. Chhangawala, K. Xu, C. S. Leslie, M. O. Li, Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism. Science 354, 481–484 (2016). [Abstract]METABOLISMQuantitation of metabolic pathway regulationMetabolomics, proteomics, and flux analysis are used to dissect quantitatively metabolic regulation in living yeast.S. R. Hackett, V. R. T. Zanotelli, W. Xu, J. Goya, J. O. Park, D. H. Perlman, P. A. Gibney, D. Botstein, J. D. Storey, J. D. Rabinowitz, Systems-level analysis of mechanisms regulating yeast metabolic flux. Science 354, aaf2786 (2016). [Abstract]CELLULAR STRUCTUREA dynamic view of the endoplasmic reticulumSuperresolution imaging shows that presumed sheets of endoplasmic reticulum comprise tightly packed, constantly changing tubules.J. Nixon-Abell, C. J. Obara, A. V. Weigel, D. Li, W. R. Legant, C. S. Xu, H. A. Pasolli, K. Harvey, H. F. Hess, E. Betzig, C. Blackstone, J. Lippincott-Schwartz, Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER. Science 354, aaf3928 (2016). [Abstract]M. Terasaki, A finer look at a fine cellular meshwork.Science 354, 415–416 (2016). [Abstract]GENE EXPRESSIONPlunging into a domain of silenceA noncoding RNA recruits the X chromosome to the nuclear periphery, spreading across the chromosome and silencing gene expression.C.-K. Chen, M. Blanco, C. Jackson, E. Aznauryan, N. Ollikainen, C. Surka, A. Chow, A. Cerase, P. McDonel, M. Guttman, Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing. Science 354, 468–472 (2016). [Abstract]