PT  - JOURNAL ARTICLE
AU  - Ferrarelli, Leslie K.
TI  - Papers of note in <em>Science Translational Medicine</em>
AID  - 10.1126/scisignal.aal4631
DP  - 2016 Nov 29
TA  - Science Signaling
PG  - ec284--ec284
VI  - 9
IP  - 456
4099  - http://stke.sciencemag.org/content/9/456/ec284.short
4100  - http://stke.sciencemag.org/content/9/456/ec284.full
SO  - Sci. Signal.2016 Nov 29; 9
AB  - DRUG DEVELOPMENTNanobodies that block gating of the P2X7 ion channel ameliorate inflammationSingle-domain antibodies called nanobodies block P2X7, an inflammatory ion channel, reducing skin and kidney inflammation in mice.W. Danquah, C. Meyer-Schwesinger, B. Rissiek, C. Pinto, A. Serracant-Prat, M. Amadi, D. Iacenda, J.-H. Knop, A. Hammel, P. Bergmann, N. Schwarz, J. Assunção, W. Rotthier, F. Haag, E. Tolosa, P. Bannas, E. Boué-Grabot, T. Magnus, T. Laeremans, C. Stortelers, F. Koch-Nolte, Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation. Sci. Transl. Med. 8, 366ra162 (2016). [Abstract]GENETIC DISORDERSTwo tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossificationTissue-specific manifestations of the congenital bone-forming syndrome FOP are mediated by multiple tissue-resident stem cell populations.D. Dey, J. Bagarova, S. J. Hatsell, K. A. Armstrong, L. Huang, J. Ermann, A. J. Vonner, Y. Shen, A. H. Mohedas, A. Lee, E. M. W. Eekhoff, A. van Schie, M. B. Demay, C. Keller, A. J. Wagers, A. N. Economides, P. B. Yu, Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification. Sci. Transl. Med. 8, 366ra163 (2016). [Abstract]