PT - JOURNAL ARTICLE AU - Adler, Elizabeth M. TI - 2016: Signaling Breakthroughs of the Year AID - 10.1126/scisignal.aam5681 DP - 2017 Jan 03 TA - Science Signaling PG - eaam5681 VI - 10 IP - 460 4099 - http://stke.sciencemag.org/content/10/460/eaam5681.short 4100 - http://stke.sciencemag.org/content/10/460/eaam5681.full SO - Sci. Signal.2017 Jan 03; 10 AB - Signaling breakthroughs of 2016 clustered mainly in the areas of neuroscience, immunology, and metabolism, with excursions into plant hormone signaling and bacterial manipulation of host signaling pathways. Perhaps reflecting the growing maturity of the discipline of cell signaling, many of this year’s breakthroughs have implications for the pathogenesis or treatment of human disease.