RT Journal Article SR Electronic T1 2016: Signaling Breakthroughs of the Year JF Science Signaling JO Sci. Signal. FD American Association for the Advancement of Science SP eaam5681 DO 10.1126/scisignal.aam5681 VO 10 IS 460 A1 Adler, Elizabeth M. YR 2017 UL http://stke.sciencemag.org/content/10/460/eaam5681.abstract AB Signaling breakthroughs of 2016 clustered mainly in the areas of neuroscience, immunology, and metabolism, with excursions into plant hormone signaling and bacterial manipulation of host signaling pathways. Perhaps reflecting the growing maturity of the discipline of cell signaling, many of this year’s breakthroughs have implications for the pathogenesis or treatment of human disease.