RT Journal Article SR Electronic T1 Papers of note in Nature 543 (7643) JF Science Signaling JO Sci. Signal. FD American Association for the Advancement of Science SP eaan0851 DO 10.1126/scisignal.aan0851 VO 10 IS 469 A1 VanHook, Annalisa M. YR 2017 UL http://stke.sciencemag.org/content/10/469/eaan0851.abstract AB This week’s articles describe a cause of chronic inflammation in Gaucher disease, a method for improving the efficacy of T cell–mediated cancer immunotherapy, a type of oncogene amplification that enhances tumor heterogeneity, and a mechanism whereby mechanical stress maintains epithelial homeostasis.