PT - JOURNAL ARTICLE AU - VanHook, Annalisa M. TI - Papers of note in <em>Science</em> <strong> 358</strong> (6366) AID - 10.1126/scisignal.aar5580 DP - 2017 Nov 28 TA - Science Signaling PG - eaar5580 VI - 10 IP - 507 4099 - http://stke.sciencemag.org/content/10/507/eaar5580.short 4100 - http://stke.sciencemag.org/content/10/507/eaar5580.full SO - Sci. Signal.2017 Nov 28; 10 AB - This week’s articles highlight structural insights into peptide loading of MHC; the mechanism by which light opens a channel protein; and how regulation of a host metabolic enzyme affects viral replication.