PT  - JOURNAL ARTICLE
AU  - Zamponi, Gerald W.
TI  - Tuning the regulator: Phosphorylation of KCC2 at two specific sites is critical for neurodevelopment
AID  - 10.1126/scisignal.aay8960
DP  - 2019 Oct 15
TA  - Science Signaling
PG  - eaay8960
VI  - 12
IP  - 603
4099  - http://stke.sciencemag.org/content/12/603/eaay8960.short
4100  - http://stke.sciencemag.org/content/12/603/eaay8960.full
SO  - Sci. Signal.2019 Oct 15; 12
AB  - The K+/Cl− cotransporter KCC2 is a molecular switch between excitatory and inhibitory effects of GABAergic inputs into neurons. In a pair of exciting studies, Watanabe et al. and Pisella et al. elucidate the role of KCC2 dephosphorylation in this process and reveal its consequences for neurodevelopment and nervous system pathology.