PT - JOURNAL ARTICLE AU - Zamponi, Gerald W. TI - Tuning the regulator: Phosphorylation of KCC2 at two specific sites is critical for neurodevelopment AID - 10.1126/scisignal.aay8960 DP - 2019 Oct 15 TA - Science Signaling PG - eaay8960 VI - 12 IP - 603 4099 - http://stke.sciencemag.org/content/12/603/eaay8960.short 4100 - http://stke.sciencemag.org/content/12/603/eaay8960.full SO - Sci. Signal.2019 Oct 15; 12 AB - The K+/Cl− cotransporter KCC2 is a molecular switch between excitatory and inhibitory effects of GABAergic inputs into neurons. In a pair of exciting studies, Watanabe et al. and Pisella et al. elucidate the role of KCC2 dephosphorylation in this process and reveal its consequences for neurodevelopment and nervous system pathology.