RT Journal Article
SR Electronic
T1 Tuning the regulator: Phosphorylation of KCC2 at two specific sites is critical for neurodevelopment
JF Science Signaling
JO Sci. Signal.
FD American Association for the Advancement of Science
SP eaay8960
DO 10.1126/scisignal.aay8960
VO 12
IS 603
A1 Zamponi, Gerald W.
YR 2019
UL http://stke.sciencemag.org/content/12/603/eaay8960.abstract
AB The K+/Cl− cotransporter KCC2 is a molecular switch between excitatory and inhibitory effects of GABAergic inputs into neurons. In a pair of exciting studies, Watanabe et al. and Pisella et al. elucidate the role of KCC2 dephosphorylation in this process and reveal its consequences for neurodevelopment and nervous system pathology.