RT Journal Article SR Electronic T1 Tuning the regulator: Phosphorylation of KCC2 at two specific sites is critical for neurodevelopment JF Science Signaling JO Sci. Signal. FD American Association for the Advancement of Science SP eaay8960 DO 10.1126/scisignal.aay8960 VO 12 IS 603 A1 Zamponi, Gerald W. YR 2019 UL http://stke.sciencemag.org/content/12/603/eaay8960.abstract AB The K+/Cl− cotransporter KCC2 is a molecular switch between excitatory and inhibitory effects of GABAergic inputs into neurons. In a pair of exciting studies, Watanabe et al. and Pisella et al. elucidate the role of KCC2 dephosphorylation in this process and reveal its consequences for neurodevelopment and nervous system pathology.