Table 1 GSEA analysis of the transcriptional response produced by Met pharmacologic inhibition in GTL16 cells. The gene sets, all statistically significant, have been selected on the basis of their functional importance and are ranked by normalized enrichment score (NES). ES, enrichment score; NOM, nominal; FDR, false discovery rate.
RankGene setSizeESNESNOM P valueFDR q value
Up
2SERUM_FIBROBLAST_CORE_DN1870.482.2<0.0010.001
11PENG_RAPAMYCIN_UP1610.441.96<0.0010.012
20CORDERO_KRAS_KD_VS_CONTROL_UP770.471.88<0.0010.02
Down
1SCHUMACHER_MYC_UP53−0.81−2.98<0.001<0.001
2PENG_RAPAMYCIN_DN192−0.63−2.85<0.001<0.001
7SERUM_FIBROBLAST_CORE_UP189−0.56−2.55<0.001<0.001
17REN_E2F1_TARGETS40−0.66−2.29<0.001<0.001
20CORDERO_KRAS_KD_VS_CONTROL_DN56−0.60−2.21<0.001<0.001