Table 1 Summary of hydrophobic motif sites phosphorylated by mTOR complexes. The phosphorylated sites are bold and underlined. Other conserved sites are bold.
SubstrateMotifmTOR complexRegulationReferences
Akt (Ser473)H F P Q F S Y S A S GmTORC2Direct(17)
SGK1 (Ser422)A F L G F S Y A P P TmTORC2Direct(20)
p70S6K (Thr389)V F L G F T Y V A P SmTORC1Direct(15, 16)
PKCα (Ser657)D F E G F S Y V N P QmTORC2Direct(8, 12)