Table 2 Summary of confirmed and potential proline-directed sites phosphorylated by mTOR complexes. The phosphorylated sites are bold and underlined. The conserved proline residues are bold.
SubstrateMotifmTOR complexRegulationReferences
Akt (Thr450)Q M I T I T P P D Q DmTORC2?(35, 36)
p70S6K (Ser371)Q T P V D S P D D S TmTORC1Direct?(38)
PKCα (Thr638)G Q P V L T P P D Q LmTORC2?(35, 36)
4E-BP1 (Thr37)G D Y S T T P G G T LmTORC1?Direct?(4447)
4E-BP1 (Thr46)T L F S T T P G G T RmTORC1?Direct?(4447)
4E-BP1 (Ser65)M E C R N S P V T K TmTORC1??(4447)
4E-BP1 (Thr70)S P V T K T P P R D LmTORC1??(4447)