Table 1

Net change in overall phosphorylation in response to kinase inhibitors.

2.5-Fold
down-regulation (%)
2.5-Fold
up-regulation (%)
Taxol0.550.66
MLN8054, 0.25 μM1.030.90
MLN8054, 1 μM2.020.88
MLN8054, 5 μM4.131.14
AZDZM2.360.92
BI2536 mitosis5.481.34
BI2536 entry7.812.76