Table 1

Rate of PTP1B reactivation by different reducing agents after inactivation with H2O2, H2S, and NO. The data are derived from three independent determinations.

H2O2 (M−1 s−1)H2S (M−1 s−1)NO (M−1 s−1)
DTTGSHTR/TRRDTTGSHTR/TRRDTTGSHTR/TRR
0.55 ± 0.10.042 ± 0.010.75 ± 0.20.24 ± 0.10.013 ± 0.01245.5 ± 2.80.83 ± 0.120.012 ± 0.00890.79 ± 0.1