Table 1

Conservation of residues equivalent to Ser275 and Ser276 in human ZIP7. Alignment of conserved residues equivalent to Ser275 and Ser276 in human ZIP7 around the consensus CK2 phosphorylation site and in a wide range of different species. The consensus motif for CK2 phosphorylation is S/TXXE, where S is Ser, T is Thr, X is any amino acid, and E is Glu. Residues fitting the CK2 phosphorylation motif are in bold. Residues in bold italics have a complementary D for Asp residue in place of Glu.

SpeciesCommon
name
No.Alignment
Homo sapiensHuman270TKEKQSSEEEEKE
Pan troglodytesChimpanzee364TKEKQSSEEEEKE
Bos taurusCow270TKEKQSSEEEEKE
Pongo abeliiOrangutan270TKEKQSSEEEEKE
Ovis ariesSheep270SKEKQSSEEEEKE
Mus musculusMouse278SKEKPSTEEE-KE
Canis familiarisDog270SKEKQSSEEEEKE
Sus scrofaPig270SKEKQSSEEEEKE
Ailuropoda melanoleucaPanda273SKEKQSSEEEEKE
Rattus norvegicusRat270SKGKPSSEDE-KE
Danio rerioZebrafish257PKSKDSDEEDDKK
Drosophila melanogasterFruit fly257PAKKKSSDKEDSG
Oncorhynchus mykissTrout265PKAKESDGEKKKK
Oryza sativaRice334PNKALSSEDSSVS
Zea maysMaize265LNYQKSDTDGKDI
Anopheles gambiaeMosquito313EAPTKSKKEEAKA
Xenopus laevisFrog276IVDDATEKEEEKD