Table 1

Calcium channel nomenclature and pharmacology. [Compiled from multiple sources, including references (7–10)]

Channel
family
Channel
subtype
Initial
protein
name
Gene namePhysiological
Name
Relative
activation
voltage
Pharmacological blockers
CaV11.1α1SCACNA1SLHigh1,4 dihydropyridine (1,4 DHP) antagonists.
Some 1,4 DHPs, such as nimodipine and nifedipine, show lower affinity for CaV1.3 and CaV1.4.
Other blockers include diltiazem and verapamil
1.2α1CCACNA1CHigh
1.3α1DCACNA1DMid
1.4α1FCACNA1FMid
CaV22.1α1ACACNA1AP/QHighω-agatoxin IVA (selective for P/Q-type)
ω-conotoxin MVIIC (selective for P/Q- and N-type)
ω-conotoxin GVIA (selective for N-type)
2.2α1BCACNA1BNHigh
2.3α1ECACNA1ERHighSNX482
CaV33.1α1GCACNA1GTLowMibefradil (poorly selective for T-type)
TTA-P2, TTA-A2 (selective for T-type)
Ni2+ (selective for CaV3.2)
3.2α1HCACNA1HLow
3.3α1ICACNA1ILow