Table 4 Effect of four Panx1 mimetic peptides on constriction of TDAs in response to phenylephrine, noradrenaline, serotonin, or endothelin-1.

The EC50 and EMAX are calculated from the data presented in Fig. 4 (B to H). EC50 represents the concentration needed to produce 50% of the maximum effect (EMAX). EMAX is expressed as the percentage of maximal diameter. Data are presented as means ± SEM. *P < 0.05 compared to no peptide using a Mann-Whitney test (n = 4 to 7).

Phenylephrine
No peptideCT1No peptideCT2
EC50 (μM)1.67 ± 1.131.43 ± 0.591.06 ± 0.324.78 ± 3.93
EMAX52.5 ± 3.3050.7 ± 9.0849.0 ± 2.4952.3 ± 4.86
No peptideIL1No peptideIL2
EC50 (μM)3.26 ± 1.531.14 ± 0.431.15 ± 0.350.57 ± 0.22
EMAX40.1 ± 5.1032.3 ± 3.8147.70 ± 1.668.6 ± 5.11*
NoradrenalineSerotoninEndothelin-1
No peptideIL2No peptideIL2No peptideIL2
EC50 (μM)0.49 ± 0.422.00 ± 1.9011.7 ± 1.655.03 ± 0.82*6.01 ± 3.740.88 ± 0.39
EMAX27.1 ± 4.6953.4 ± 7.00*38.6 ± 5.7036.7 ± 3.5238.2 ± 6.6741.9 ± 3.73