Table 1 SILAC heatmap representation of the temporal changes in the extent of tyrosine phosphorylation of proteins associated with the KEGG (Kyoto Encyclopedia of Genes and Genomes) TCR signaling pathway.

Heatmaps were calculated from five independent biological replicate experiments. Green represents enhanced phosphorylation in response to ZAP-70 inhibition, whereas red represents a decrease in the phosphorylation of the indicated proteins relative to that in DMSO-treated control cells. White dots in the heatmap indicate statistically significant differences (Q value < 0.05) for those time points. Below each heatmap square is a color bar representing the percentage confidence value (CV) for the indicated times. PI3K, phosphatidylinositol 3-kinase; RXR-α, retinoid X receptor α; MAPK14, mitogen-activated protein kinase 14.

Table 1