Table 2 Micromolar IC50 values for XMD17-109 in different ECs.

n.d., no data.

AgonistHUVECsHMVEC-lung
cells
IL-6IL-8IL-6IL-8
Pam3Cys
  10 μg/ml0.380.390.390.45
FSL-1
  10 μg/ml2.021.830.820.79
LPS
  10 μg/ml0.800.740.661.17
  1 μg/ml1.371.880.680.96
TNF-α
  10 ng/ml0.612.630.430.59
IL-1β
  10 ng/ml3.463.68n.d.n.d.
  1 ng/ml3.261.980.580.67
  0.1 ng/ml0.580.630.410.48
Average IC501.561.720.570.73