Table 1 MAPK pathway inhibitors produce differential apoptotic responses in the mouse intestinal epithelium.
TreatmentpERK amountpMEK amountRelative apoptotic phenotypeCC3/tubulin AUC
DMSOHighHighLate, high2.52
PD325901LowHighEarly, high2.27
SCH772984LowLowLate, low1.48
MLN2480HighLowEarly, low1.03