Fold changes in expression of mRNAs encoding aminoacyl tRNA synthetases in HCT116 and RKO cells in response to 18 and 48 hours treatment of ONC201, as determined by microarray analyses (data files S1 to S7).
| Aminoacyl tRNA synthetase | Fold change versus untreated |
| 18 hours of ONC201 incubation | |
| HCT116 | |
| Cysteinyl-tRNA synthetase (CARS) | 3.4 |
| CARS | 2.5 |
| Seryl-tRNA synthetase (SARS) | 2.4 |
| Alanyl-tRNA synthetase (AARS) | 2.2 |
| Glycyl-tRNA synthetase (GARS) | 2.2 |
| Tryptophanyl-tRNA synthetase (WARS) | 2 |
| Tyrosyl-tRNA synthetase (YARS) | 2 |
| Leucyl-tRNA synthetase (LARS) | 1.8 |
| Isoleucyl-tRNA synthetase (IARS) | 1.7 |
| 48 hours of ONC201 incubation | |
| HCT116 | |
| GARS | 2.2 |
| RKO | |
| SARS | 1.9 |
| WARS | 1.8 |
| WARS | 1.6 |