Table 1 ONC201 induces the expression of mRNAs encoding aminoacyl tRNA synthetases.

Fold changes in expression of mRNAs encoding aminoacyl tRNA synthetases in HCT116 and RKO cells in response to 18 and 48 hours treatment of ONC201, as determined by microarray analyses (data files S1 to S7).

Aminoacyl tRNA synthetaseFold change versus
untreated
18 hours of ONC201 incubation
HCT116
Cysteinyl-tRNA synthetase (CARS)3.4
CARS2.5
Seryl-tRNA synthetase (SARS)2.4
Alanyl-tRNA synthetase (AARS)2.2
Glycyl-tRNA synthetase (GARS)2.2
Tryptophanyl-tRNA synthetase (WARS)2
Tyrosyl-tRNA synthetase (YARS)2
Leucyl-tRNA synthetase (LARS)1.8
Isoleucyl-tRNA synthetase (IARS)1.7
48 hours of ONC201 incubation
HCT116
GARS2.2
RKO
SARS1.9
WARS1.8
WARS1.6