Table 3 Size and strength properties of the engineered mice (second cohort).

au, arbitrary units; WT, wild type.

MeasureNumber of mice
per genotype tested
or experiments
WTT991A/+T991A/T991AWT versus
T991A/+
(P)
WT versus
T991A/T991A
(P)
T991A/+ versus
T991A/T991A
(P)
Mass (g)6, 7, and 627.1 ± 1.931.3 ± 1.622.7 ± .480.150.140.002
Rotarod7, 7, and 7169 ± 11191 ± 1183 ± 60.730.020.0045
12-mm beam (time to
cross the beam, s)
6, 7, and 66.3 ± 0.955 ± 0.316.38 ± 1.60.730.0040.0005
12-mm beam
(paw slips)
6, 7, and 60.05 ± 0.060.08 ± 0.069.9 ± 1.040.740.00010.0001
6-mm beam
(failure to cross)
6, 7, and 61 of 6 mice in 1 of 3 trials02 of 6 mice in 2 of 3 trialsN/AN/AN/A
6-mm beam
(neurological score)
6, 7, and 66.4 ± 0.336.6 ± 0.212.1 ± 0.260.840.00010.0001
Grip test by wire
hang (time)
6, 7, and 627 ± 4.817.3 ± 3.238.8 ± 5.60.550.460.07
Force grip
test (N/g)
6, 7, and 6−0.045 ± 0.002−0.041 ± 0.002−0.051 ± 0.0010.850.100.03