Table 4 Nerve conduction measurements in engineered mice.

Sensory and motor signals were measured in the dorsal caudal nerve (tail) and sciatic nerve (nerve) in WT, heterozygous (T991A/+), and homozygous (T991A/T991A) mice. Significance was tested by one-way ANOVA followed by Tukey’s multiple comparison tests.

MeasureNerve/
signal
WTT991A/+T991A/T991AMice per
genotype
WT versus
T991A/+
(P)
WT versus
T991A/T991A
(P)
T991A/+ versus
T991A/T991A
(P)
AmplitudeCaudal/sensory265 ± 30218 ± 61213 ± 346, 6, and 60.730.680.99
Sciatic/sensory235 ± 78192 ± 16272 ± 775, 5, and 60.890.920.67
Caudal/motor2657 ± 6342578 ± 770943 ± 2155, 6, and 60.990.140.14
Sciatic/motor6521 ± 14204223 ± 11185393 ± 16616, 6, and 60.500.840.83
LatencyCaudal/sensory1.58 ± 0.061.61 ± 0.041.70 ± 0.095, 6, and 60.950.380.51
Sciatic/sensory1.88 ± 0.331.71 ± 0.362.11 ± 0.155, 5, and 60.910.830.58
Caudal/motor3.20 ± 0.273.20 ± 0.534.80 ± 0.406, 6, and 60.990.030.03
Sciatic/motor2.74 ± 0.372.34 ± 0.113.50 ± 0.486, 6, and 60.720.320.09