Table 2 Single AP waveform characteristics of control and RG108-treated neurons.

These values represent the neurons used for Fig. 5. All values are means ± SEM. *P < 0.05, Student’s t test. n, number of cells; Vthr, voltage threshold.

Treatment (n)CTL (10)RG108 (13)
AP waveform
Vthr (mV)−45.1 ± 0.8−48.8 ± 0.7*
Maximal depolarization rate (mV/ms)75.4 ± 4.280.9 ± 3.7
Amplitude (mV)75.0 ± 2.480.0 ± 1.8
Maximal repolarization rate (mV/ms)32.5 ± 3.432.5 ± 2.7
One-half width (ms)2.5 ± 0.22.5 ± 0.1
fAHP (mV)−13.0 ± 1.1−12.3 ± 1.2
mAHP (mV)−21.2 ± 1.1−17.2 ± 1.0*
Time-to-peak AHP (ms)41.5 ± 3.038.6 ± 2.5