Table 1 Passive membrane properties of the analyzed neurons exposed to various treatments.

All values are means ± SEM. *P < 0.05, Student’s t test. n, number of cells; Vm, resting membrane potential; Rinput, input resistance; τ, membrane time constant; Cm, membrane capacitance; ActD, actinomycin D.

FigureTreatmentnVm (mV)Rinput (megohms)τ (ms)Cm (pF)
1CTL16−57.6 ± 1.1570 ± 3962.7 ± 4.758.3 ± 2.6
RG10816−62.1 ± 1.7*575 ± 5263.6 ± 5.966.7 ± 5.6
2CTL7−60.1 ± 1.3606 ± 7563.3 ± 5.665.7 ± 4.4
RG108 + APV5−60.4 ± 3.2478 ± 8066.4 ± 6.767.2 ± 8.3
RG108 + NBQX + APV7−58.4 ± 2.1527 ± 5067.9 ± 7.469.2 ± 6.3
RG108 + TTX7−58.7 ± 1.9590 ± 9677.9 ± 13.458.2 ± 5.8
3CTL11−59.3 ± 1.2589 ± 5961.1 ± 4.760.9 ± 3.6
RG108 + ActD4−59.3 ± 4.1579 ± 15364.1 ± 10.646.3 ± 2.0
Scrambled CTL6−57.3 ± 1.5594 ± 3062.6 ± 4.167.0 ± 5.4
Tet1 ASO + RG1087−61.0 ± 1.7619 ± 12160.8 ± 5.252.7 ± 7.2
5CTL10−59.0 ± 1.3621 ± 5362.2 ± 4.755.6 ± 5.1
RG10813−62.6 ± 1.2599 ± 5962.9 ± 6.160.7 ± 3.7
6 (A to E)Scrambled CTL12−56.8 ± 1.1516 ± 3259.5 ± 3.955.5 ± 4.2
Dnmt1 ASO9−58.9 ± 1.2613 ± 8361.0 ± 4.656.9 ± 7.4
Dnmt3a ASO7−60.7 ± 2.0626 ± 6166.6 ± 7.250.4 ± 3.5
6 (F to H)Scrambled CTL8−57.0 ± 1.0541 ± 3556.8 ± 4.160.8 ± 4.8
Dnmt1 ASO5−58.4 ± 2.0507 ± 2255.0 ± 4.565.4 ± 11.6
Dnmt3a ASO5−63.4 ± 2.0670 ± 7170.3 ± 9.355.2 ± 8.1
7 (A and B, and E and F)CTL8−56.4 ± 1.0634 ± 5463.0 ± 5.850.4 ± 5.0
CTL + apamin5−58.4 ± 3.0704 ± 4173.3 ± 4.354.9 ± 5.3
RG10810−62.0 ± 1.4610 ± 6861.6 ± 6.556.5 ± 2.8
RG108 + apamin4−59.8 ± 4.0683 ± 11067.8 ± 5.758.1 ± 4.0
7 (C and D, and G and H)CTL18−58.1 ± 1.1570 ± 3862.3 ± 4.260.3 ± 2.7
CTL + apamin5−58.4 ± 3.0704 ± 4173.3 ± 4.354.9 ± 5.3
RG10819−62.7 ± 1.5575 ± 4863.5 ± 5.467.1 ± 5.1
RG108 + apamin4−59.8 ± 4.0683 ± 11067.8 ± 5.758.1 ± 4.0