Table 3 Single AP waveform characteristics of scrambled CTL, Dnmt1 ASO–treated, and Dnmt3a ASO–treated neurons in Fig. 6.

All values are means ± SEM. *P < 0.05, one-way ANOVA followed by Dunnett’s test. n, number of cells.

Treatment (n)Scrambled CTL (9)Dnmt1 ASO (5)Dnmt3a ASO (5)
AP waveform
Vthr (mV)−45.2 ± 1.1−48.4 ± 1.6−49.6 ± 1.6
Maximal depolarization rate (mV/ms)78.6 ± 4.781.4 ± 6.582.0 ± 2.5
Amplitude (mV)75.8 ± 3.379.5 ± 3.182.1 ± 1.8
Maximal repolarization rate (mV/ms)28.8 ± 7.637.8 ± 5.431.4 ± 4.5
One-half width (ms)2.2 ± 0.12.2 ± 0.22.6 ± 1.8
fAHP (mV)−14.9 ± 0.7−12.4 ± 1.0−12.1 ± 0.8*
mAHP (mV)−22.8 ± 1.1−18.8 ± 1.0*−16.2 ± 1.0*
Time-to-peak AHP (ms)37.9 ± 2.238.6 ± 3.341.8 ± 1.3