Atg5 | Total knockout | WAT development is impaired. | (40) |
Atg5 | MEFs in vitro | MEFs from total knockout mice have defects in white adipocyte differentiation in culture. | (40) |
Atg5 | Ucp1-Cre | Beige adipocytes are maintained in the absence of browning stimuli and retain mitochondria and UCP1. | (39) |
Atg7 | aP2-Cre | WAT is reduced and adipocytes have increased mitochondrial content with small lipid droplets. WAT in knockout mice contains increased numbers of beige adipocytes. Mice are protected from diet-induced obesity and insulin resistance. | (42, 43) |
Atg7 | Myf5-Cre | Deletion in Myf5+ progenitors impairs BAT development and promotes beige fat development. | (41) |
Atg7 | Mlclf-Cre | Deletion in skeletal muscle induces browning of WAT. | (47) |
Atg7 | Pomc-Cre | Deletion in POMC neurons induces browning of WAT. | (71) |
Atg12 | Ucp1-Cre | Beige adipocytes are maintained in the absence of browning stimuli and retain mitochondria and UCP1. Mice are protected from diet-induced obesity and insulin resistance. | (39) |
p62 | Total knockout | Enlarged adipocytes due to lipid accumulation. Mice are obese, glucose intolerant, and have decreased insulin sensitivity. | (106) |
p62 | aP2-Cre | Brown adipocytes accumulate defective mitochondria and have more lipid droplets. Mice are obese, glucose intolerant, and have decreased insulin sensitivity. | (44) |
Parkin | Total knockout | Mice are resistant to high-fat diet–induced obesity. EpiWAT and BAT of these mice accumulate less lipid in response to a high-fat diet. | (107) |
Raptor | Adiponectin-Cre | Browning of WAT is disrupted in response to chronic cold exposure. | (56) |