Table 1 Drugs targeting the UPR.

Names, structures, and target of molecules identified to target directly the ATF6 (green), IRE1 (pink), or PERK (yellow) pathways. All the molecules indicated are inhibitors except for compounds 147 and 263 that activate ATF6.

PathwayNameStructureTargetReference
ATF616F16GraphicPDI(58)
CeapinsGraphicATF6(126, 127)
Compound 147GraphicActivators of
ATF6
(128)
Compound 263Graphic
IRE14μ8cGraphicIRE1 RNase(129)
MKC analogsGraphicIRE1 RNase(130133)
3-Ethoxy-5,6-
dibromosalicylaldehyde
GraphicIRE1 RNase(130)
KIRA6GraphicIRE1 kinase(134)
STF-083010GraphicIRE1 RNase(135)
Compound 3GraphicIRE1 kinase(136)
PERKGSK2656157GraphicPERK(44)
ISRIBGraphiceIF2β(137)
SalubrinalGraphicGADD34 (PP1c)(138)
GuanabenzGraphicGADD34 (PP1c)(139)
Sephin 1/IFB-088GraphicGADD34 (PP1c)(140)