Table 1 Grade and distribution of prostate lesions.

Histopathological categorization of H&E-stained prostatic lobes from WT and PSMA KO tumors. Number of lesions in each lobe are assigned by grade [hyperplasia (grades 2 to 3), adenoma (grades 4 to 5), or adenocarcinoma (grade 6)] and distribution (focal, multifocal, or diffuse).

Treatment group
and lobe
Grade 2Grade 3Grade 4Grade 5Grade 6
FocalMultifocalDiffuseFocalMultifocalDiffuseFocalMultifocalDiffuseFocalMultifocalDiffuseFocalMultifocalDiffuse
Anterior lobe
  Week 8
    WT (n = 26)38375
    KO (n = 19)47322
  Week 18
    WT (n =2 7)3285513
    KO (n = 23)7844
  Week 30
    WT (n = 16)43522
    KO (n = 16)124422
Dorsal lobe
  Week 8
    WT (n = 27)712521
    KO (n = 21)353721
  Week 18
    WT (n = 27)1139222
    KO (n = 23)18653
  Week 30
    WT (n = 16)4352
    KO (n = 17)242124
Ventral lobe
  Week 8
    WT (n = 29)23261312
    KO (n = 21)353721
  Week 18
    WT (n = 27)13788
    KO (n = 23)314411
  Week 30
    WT (n = 18)23421411
    KO (n = 19)16312312