Table 1 The receptors, receptor–accessory proteins, and endogenous inhibitors of the IL-1 family of cytokines.

IL-1 family members (in bold) are grouped into four subfamilies. The receptors and receptor–accessory proteins that transduce signals from each family member are listed, as well as inhibitors of signaling. The nomenclature used here follows that of the HUGO Gene Nomenclature Committee for ILs (www.genenames.org/cgi-bin/genefamilies/set/601) and IL receptors (www.genenames.org/cgi-bin/genefamilies/set/602).