Table 1 PIK3CA and PTEN mutational status of breast cancer cell lines studied.

N.D., not determined; WT, wild-type.

GroupCell linePIK3CA mutation status*PTEN mutation status*PTEN protein abundance
AHCC70WT267delT (F90fs*9)Negative
HCC38WTWTNegative
SUM149WTWTNegative
BMDA-MB-231WTWTPositive
HCC1806WTWTPositive
HCC1143WTWTN.D.
SKBR3WTWTPositive
BT-549WT821delG (V275fs*1)Negative
ZR-75-1WT323T > G (L108R)Positive
SUM-1593140A > T (H1047L)WTPositive
CT47D3140A > G (H1047R)WTPositive
MCF71633G > A (E545K)WTPositive
MDA-MB-468WT253 + 1G > T (A72fs*5)Negative

*Reported in Catalogue of Somatic Mutations in Cancer database [http://cancer.sanger.ac.uk; (64)].

†Reported in refs. (50) and (65).

‡Reported in ref. (66).