Table 1 TNFRSF receptors, their ligands, and their intracellular binding partners.

TNFRSF members can be classified into three groups based on their downstream interaction partners. Some receptors can be activated by more than one ligand. EDARADD, EDAR-associated DD; NADE, neurotrophin-associated cell death executor; NGF, nerve growth factor; NGFR, NGF receptor; n/a, not applicable.

TNFRSF receptor (TNFRSF#, other names)Intracellular binding partnerTNFSF ligand (TNFSF#, other names)
Death receptors
  TNFR1 (1a, CD120a)TRADD, FADD, RIPTNF (2, TNF-α), LTα (1, TNF-β), LTβ (3)
  Fas (6, CD95)FADDFasL (6, CD178)
  TRAILR1 (10A, DR4, CD261)FADD, TRADD, RIPTRAIL/Apo2L (10, CD253)
  TRAILR2 (10B, DR5, CD262)FADD, TRADD, RIPTRAIL/Apo2L (10, CD253)
  NGFR (16, p75NTR, CD271)NADENGF (not a TNFSF member)
  DR3 (25 or 12, TRAMP)TRADD, FADDTL1A (15, VEGI), TWEAK (12)
  DR6 (21, CD358)TRADD, RIPN-APP (not a TNFSF member)
Receptors with TRAF-interacting motif (82)
  TNFR2 (1b, CD120b)TRAF1–3TNF (2, TNF-α), LTα (1, TNF-β), LTβ (3)
  LTβR (3)TRAF2, TRAF3, TRAF5LTβ (3), LTαβ2
  OX40 (4, CD134)TRAF1–3, TRAF5, TRAF6OX40L (4, CD252)
  CD40 (5)TRAF1–3, TRAF5, TRAF6CD40L (5, CD154)
  CD27 (7)TRAF2, TRAF3, TRAF5CD27L (7, CD70)
  CD30 (8)TRAF1–3, TRAF5CD30L (8, CD153)
  4-1BB (9, CD137)TRAF1–34-1BBL (9, CD137L)
  RANK (11A, CD265)TRAF1–3, TRAF5, TRAF6RANKL (11, TRANCE, CD254)
  Fn14 (12A, TWEAKR; CD266)TRAF2, TRAF6TWEAK (12)
  TACI (13B, CD267)TRAF2–3, TRAF5, TRAF6APRIL (13, CD256)
  BAFFR (13C, BR3, CD268)TRAF2, TRAF3, TRAF6BAFF (13B/20, BLys, THANK, CD257)
  HVEM (14, CD270)TRAF1–3, TRAF5LIGHT (14, CD258), LTα (1, TNF-β)
  BCMA (17, CD269)TRAF1–3, TRAF5, TRAF6APRIL (13, CD256), BAFF (13B/20, BLys, THANK, CD257)
  GITR (18, AITR, CD357)TRAF1–5GITRL (18, AITRL, TL6)
  RELT (19L)TRAF1?
Decoy receptorsn/a
  TRAILR3 (10C, DcR1, CD263)TRAIL/Apo2L (10, CD253)
  TRAILR4 (10D, DcR2, CD264)TRAIL/Apo2L (10, CD253)
  OPG (11B)TRAIL/Apo2L (10, CD253), RANKL (11, TRANCE,
  DcR3 (6B)FasL (6), TL1A (15, VEGI), LIGHT (14, CD258)