Table 2 The increased catalytic activity of SHP2E76K is required for its detrimental effect on ependymal cell development.

Ptpn11E76K,C459S/+ double-mutation knockin and Ptpn11E76K/+ single-mutation knockin mice were monitored for 15 months. The incidences of frank hydrocephalus in the euthanized animals were documented.

Mice*Incidence of frank
hydrocephalus
Ptpn11E76K/+/Nestin-Cre+26/56
Ptpn11+/+/Nestin-Cre+0/58
Ptpn11E76K,C459S/+0/56
Ptpn11+/+0/44

*Mice were monitored for 15 months.