Table 2 EC50 values for the 3-ketosteroid transcriptional activation of GAL4-DBD-MR-LBD of vertebrate MRs.

The percentage relative induction is compared to the maximal response to ALDO.

MRALDOCorticosteroneCortisol11-Deoxycorticosterone11-Deoxycortisol
EC50 (M)EC50 (M)EC50 (M)EC50 (M)EC50 (M)
Human2.8 × 10−105.9 × 10−103.2 × 10−91.8 × 10−9
100%95%74%44%8%
Chicken1.3 × 10−101.6 × 10−106.9 × 10−101.7 × 10−104.7 × 10−9
100%92%75%92%36%
Alligator3.5 × 10−103.8 × 10−102.3 × 10−95.2 × 10−10
100%88%68%51%8%
Xenopus1.5 × 10−91.9 × 10−91.2 × 10−8
100%74%37%10%6%
Zebrafish2.7 × 10−111.5 × 10−103.1 × 10−101.0 × 10−109.1 × 10−10
100%96%77%99%67%