Table 1 EC50 values for the 3-ketosteroid transcriptional activation of full-length vertebrate MRs.

The percentage relative induction is compared to the maximal response to ALDO.

MRALDOCorticosteroneCortisol11-Deoxycorticosterone11-Deoxycortisol
EC50 (M)EC50 (M)EC50 (M)EC50 (M)EC50 (M)
Human2.7 × 10−101.2 × 10−95.5 × 10−94.2 × 10−103.6 × 10−9
100%119%133%74%42%
Chicken6.2 × 10−115.1 × 10−112.8 × 10−103.4 × 10−116.7 × 10−10
100%109%128%110%112%
Alligator2.8 × 10−103.6 × 10−106.9 × 10−92.3 × 10−102.7 × 10−9
100%138%176%85%45%
Xenopus4.6 × 10−106.2 × 10−101.1 × 10−87.6 × 10−109.1 × 10−9
100%105%126%59%31%
Zebrafish8.2 × 10−113.0 × 10−104.4 × 10−106.3 × 10−114.0 × 10−10
100%112%123%103%94%