Table 4 In vitro early ADMET analysis of TSI-13-57.

Absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of TSI-13-57 were analyzed in vitro to assess suitability for in vivo applications. CLint, intrinsic clearance.

Cytotoxicity EC50 (μM)
HEK293>18.5
HepG2>18.5
Raji>18.5
Solubility (μM)pH 7.414.4 ± 5
Permeability (×10−6 cm/s)pH 7.4112.6 ± 35
Stability mouse liver microsomes (t1/2) (hours)>4
CLint (ml min−1 kg−1)<13.5