Table 1 Properties of the major Aurora complexes.
Scaffold
protein
Other
core
subunits
Catalytic
subunit
Aurora kinase
activation
mechanism
Downstream
kinase
Localization
to mitotic
structures
Spindle
assembly
pathway and
mechanism
Function of the
complex
References
BoraAurASubstrate preference
for PLK1
PLK1CytoplasmPLK1 activation in
the cytoplasm
before and during
mitosis, mitotic
entry control
(41, 42, 71, 132, 137)
CEP192AurAOligomerization-
dependent T-loop
autophosphorylation
PLK1*CentrosomesCentrosome-
driven; MT
nucleation and
anchoring
Centrosome
maturation and
separation,
generation of
astral and spindle
MTs
(39, 47, 48, 75, 76)
TPX2AurABinding-mediated
allostery
Spindle MTsChromatin-driven
and MT-driven;
MT nucleation
and bundling
Generation and
amplification of
spindle MTs
(3, 53, 54, 5760, 65,
426)
INCENPSurvivin,
Borealin
AurB or
AurC
Oligomerization-
dependent T-loop
autophosphorylation
PLK1*Chromosome
arms,
centromeres,
kinetochores,
central
spindle,
midbody
Kinetochore-
driven; MT
stabilization and
bundling
Chromosome
dynamics and
cohesion,
kinetochore-MT
attachments,
spindle assembly
checkpoint,
cytokinesis
(25, 40, 4446, 145,
160, 193)

*CEP192 and INCENP recruit most of the cognate Aurora kinase associated with the indicated mitotic structures. In contrast, PLK1 is recruited to the corresponding mitotic structures not only by CEP192 and INCENP but also by other proteins.