Table 2 Summary of fitted curve parameters for Ca2+ flux.

EC50, pEC50, and Emax values with SEM are given for Fig. 5, left column. ND, not detectable.

RANTESMIP-5P125P146P4PSC
CCR5
  EC50 (nM)32240ND213625
  pEC50 ± SEM−7.6 ± 0.2−6.5 ± 0.2ND−7.7 ± 0.7−7.4 ± 0.1−7.6 ± 0.1
  Emax ± SEM12,000 ± 100015,000 ± 2000ND3000 ± 100045,000 ± 200031,000 ± 2000
CCR5 + Gi2
  EC50 (nM)NDNDNDND11042
  pEC50 ± SEMNDNDNDND−6.9 ± 0.3−7.4 ± 0.3
  Emax ± SEMNDNDNDND15,000 ± 300010,000 ± 2000
CCR5 + Gq
  EC50 (nM)32460NDND2126
  pEC50 ± SEM−7.5 ± 0.1−6.3 ± 0.3NDND−7.7 ± 0.1−7.6 ± 0.1
  Emax ± SEM20,000 ± 200027,000 ± 8000NDND61,000 ± 400064,000 ± 2000
CCR5 + Gqi5
  EC50 (nM)0.95.1233.60.71.8
  pEC50 ± SEM−9.0 ± 0.1−8.3 ± 0.1−7.6 ± 0.1−8.4 ± 0.1−9.1 ± 0.1−8.7 ± 0.1
  Emax ± SEM50,000 ± 400050,000 ± 300019,000 ± 100045,000 ± 200077,000 ± 400067,000 ± 3000