Table 3 Summary of fitted curve parameters for IP1 accumulation.

EC50, pEC50, and Emax values are given for Fig. 5, right column. ND, not detectable.

RANTESMIP-5P125P146P4PSC
CCR5
  EC50 (nM)NDNDNDNDND190
  pEC50 ± SEMNDNDNDNDND−6.7 ± 0.4
  Emax ± SEMNDNDNDNDND1.7 ± 0.3
CCR5 + Gi2
  EC50 (nM)NDNDNDNDNDND
  pEC50 ± SEMNDNDNDNDNDND
  Emax ± SEMNDNDNDNDNDND
CCR5 + Gq
  EC50 (nM)65NDND4.31872
  pEC50 ± SEM−7.2 ± 0.4NDND−8.3 ± 0.3−7.7 ± 0.1−7.1 ± 0.1
  Emax ± SEM1.0 ± 0.2NDND1.6 ± 0.37.4 ± 0.18.4 ± 0.1
CCR5 + Gqi5
  EC50 (nM)62.90.50.63.525
  pEC50 ± SEM−8.2 ± 0.1−8.5 ± 0.1−9.3 ± 0.4−9.2 ± 0.2−8.5 ± 0.1−7.6 ± 0.1
  Emax ± SEM3.1 ± 0.33.0 ± 0.22.3 ± 0.45.3 ± 0.45.8 ± 0.55.4 ± 0.3