Table 1 Activation of full-length MR and truncated MRs (LBD) by corticosteroids.

Analysis of luciferase activity in the presence of corticosteroids as a percentage of the luciferase activity induced by Aldo alone. Statistical analysis was performed as described previously (36). DOC, 11-deoxycorticosterone.

MRAldoCorticosteroneCortisolDOCDOC
EC50 (M)EC50 (M)EC50 (M)EC50 (M)EC50 (M)
Elephant shark full1.1 × 10−101.7 × 10−104.6 × 10−106.3 × 10−111.1 × 10−10
100%101%114%83%83%
Elephant shark LBD3.7 × 10−119.9 × 10−111.9 × 10−102.4 × 10−116.8 × 10−11
100%90%79%81%77%
Skate LBD*7 × 10−111 × 10−101 × 10−93 × 10−112.2 × 10−8
Human full2.7 × 10−101.2 × 10−95.5 × 10−94.2 × 10−103.6 × 10−9
100%119%133%74%42%
Human LBD2.8 × 10−105.9 × 10−103.2 × 10−91.8 × 10−9
100%95%74%44%8%§
Chicken full6.2 × 10−115.1 × 10−112.8 × 10−103.4 × 10−116.7 × 10−10
100%109%128%110%112%
Chicken LBD1.3 × 10−101.6 × 10−106.9 × 10−101.7 × 10−104.7 × 10−9
100%92%75%92%36%
Alligator full2.8 × 10−103.6 × 10−106.9 × 10−92.3 × 10−102.7 × 10−9
100%138%176%85%45%
Alligator LBD3.5 × 10−103.8 × 10−102.3 × 10−95.2 × 10−10
100%88%68%51%8%§
Xenopus full4.6 × 10−106.2 × 10−101.1 × 10−87.6 × 10−109.1 × 10−9
100%105%126%59%31%
Xenopus LBD1.5 × 10−91.9 × 10−91.2 × 10−8
100%74%37%10%§6%§
Zebrafish Full8.2 × 10−113.0 × 10−104.4 × 10−106.3 × 10−114.0 × 10−10
100%112%123%103%94%
Zebrafish LBD2.7 × 10−111.5 × 10−103.1 × 10−101.0 × 10−109.1 × 10−10
100%96%77%99%67%

*Values obtained from Carroll et al. (49).

†Values obtained from Katsu et al. (36).

‡Curve did not saturate.

§Relative induction at 1 μM compared to Aldo.