Table 2 Rate constants.
ReactionsRate constant k (1/s)
Activated ZAP70 phosphorylates LAT, kzl0.05
Activated ZAP70 phosphorylates p38, kzp0.005
pLAT self-decays to the inactive form, kdl1
GPS binds to pLAT, kbg0.0001
GPS unbinds to pLAT, kug5
GPS-LAT complex phosphorylates p38, ka0.1
pp38 self-decays to the inactive form, kdp40
The positive feedback of pp38 to GPS-LAT
complex, kf
0.01