Table 1 RTKs that mediate pathogen entry.

AAV2 and AAV3, adeno-associated viruses 2 and 3; AcMAPV, autographica californica multicapsid nucleopolyhedrovirus; AMAV, Amapari virus; CHIKV, chikungunya virus; DENV, dengue virus; EBOV, Ebola virus; EEEV, eastern equine encephalitis virus; HCMV, human cytomegalovirus; HCV, hepatitis C virus; HPV, human papillomavirus; IAV, influenza A virus; HSV-1, herpes simplex virus 1; JEV, Japanese encephalitis virus; KSHV, Kaposi’s sarcoma-associated herpesvirus; LASV, Lassa virus; LCMV, lymphocytic choriomeningitis virus; MARV, Marburg virus; PICV, Pichinde virus; RRV, Rose River virus; RSV, respiratory syncytial virus; SARSV, severe acute respiratory syndrome virus; SINV, Sindbis virus; SV40, simian virus 40; TCRV, Tacaribe virus; TGEV, porcine transmissible gastroenteritis virus; PRRSV, porcine reproductive and respiratory syndrome virus; VACV, vaccinia virus; VSV, vesicular stomatitis virus; WNV, West Nile virus; YFV, yellow fever virus; ZIKV, Zika virus.

KinasePathogen classPathogen speciesMode of interactionsKinase activity required?References
AxlVirusCHIKV, RRV, EEEV, SINV,
AMAV, LASV, lentivirus, PICV,
LCMV, TCRV, EBOV, MARV,
AcMAPV, DENV, ZIKV, WNV,
YFV, VACV, VSV, SV40
Indirect: Gas6DENV: No
ZIKV: Yes
All other viruses: ?
(1517)
Tyro3VirusDENVIndirect: Gas6?(20)
ZIKV?Yes(16, 17)
SV40Direct?(15)
FGFRVirusAAV2 and AAV3?No(94)
IAV?Yes(95)
HPV?Yes(96)
BacteriaChlamydia trachomatisIndirect: FGF2Yes(39, 97)
EphA2VirusKSHV, HCVDirectKSHV: Yes
HCV: ?
(46, 98)
BacteriaChlamydia trachomatisDirectYes(97)
EGFRVirusHCMVDirectYes(33, 34, 99)
HCV, HPV, IAV, RSV, SARSV?Yes(32)
EBOV?Yes(100)
LASV?Yes(100)
PRRSVIndirect: Syndecan-4Yes(101)
TGEV?Yes(57)
JEV?Yes(66)
HSV-1?Yes(58)
BacteriaCampylobacter jejuni,
Shigella flexneri
?Yes(32, 102)
Salmonella typhimuriumDirectYes(72)
Chlamydia pneumoniaeDirectYes(32, 97)
FungiCandida albicansDirectYes(103)
Her2 (ErbB2)BacteriaM. lepraeDirectYes(32)
N. meningitidis?Yes(32)
FungiCandida albicans (Als1 and
Ssa1 proteins)
DirectYes(103)
PDGFRVirusHCMVDirectYes(34)
IAV??(104)
BacteriaChlamydia trachomatisDirectYes(39, 97)
Campylobacter Jejuni?Yes(32)
c-MetVirusAAV2Direct?(94)
IAV?Yes(56)
EBOV?Yes(105)
BacteriaL. monocytogenes (InlB)DirectYes(106)
ProtistPlasmodium berghei
sporozoites
NoYes(55)
TrkCProtistTrypanosoma cruziDirectYes(107)